کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8311827 | 1538665 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Matrix metalloproteinase 9 (MMP-9) in osteosarcoma: Review and meta-analysis
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کلمات کلیدی
BBDCBMMMP-9CNKItrue-negativeAUC - AUCOsteosarcoma - استئوسارکوماDiagnosis - تشخیصDOR - دردTrue-positive - درست مثبتMeta-analysis - فرا تحلیل Matrix metalloproteinase 9 - ماتریکس متالوپروتئیناز 9False-positive - مثبت کاذبarea under the receiver operating characteristic curve - محدوده تحت منحنی مشخصه عملکرد گیرندهFalse-negative - منفی اشتباهdiagnostic odds ratio - نسبت شانس تشخیصی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The aim of this study is to determine the value of matrix metalloproteinase 9 (MMP-9) in diagnosis of osteosarcoma (OS). A systematic review and meta-analysis was conducted using MEDLINE, Embase, ISI Web of Knowledge, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, China Biomedical literature Database (CBM) and China National Knowledge Internet (CNKI) from inception through Aug 29, 2013. Articles written in English or Chinese that investigated the accuracy of MMP-9 for the diagnosis of OS were included. Pooled sensitivity, specificity and the area under the receiver operating characteristic curve (AUC) were determined. I2 was used to test heterogeneity and source of heterogeneity was investigated by meta-regression (tested with Meta-DiSc and STATA 12.0 statistical softwares). A total of 3729 articles were retrieved, of which 18 were included, accounting for 892 patients. Overall, the pooled sensitivity, specificity and AUC were 0.78 (95% CI 0.730-0.83), 0.90 (95% CI 0.79-0.95), and 0.87 (95% CI 0.83-0.89), respectively. The studies had substantial heterogeneity (I2Â =Â 84%, 95% CI 65-100) (96%, 95% CI 94-99). Assay kit subgroup was the main source of the heterogeneity. Although MMP-9 was identified as a potential biomarker for OS, more studies were clearly needed to establish its diagnostic value.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 433, 10 June 2014, Pages 225-231
Journal: Clinica Chimica Acta - Volume 433, 10 June 2014, Pages 225-231
نویسندگان
Jing Wang, Qiong Shi, Tai-xian Yuan, Qi-lin Song, Yan Zhang, Qiang Wei, Lan Zhou, Jinyong Luo, Guowei Zuo, Min Tang, Tong-Chuan He, Yaguang Weng,