Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion

► Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) levels in failed pregnancy were measured in maternal serum. ► ANG-1 and ANG-2 are significantly decreased in failed than normal pregnancies. ► Serum ANG-1 showed potential to discriminate missed abortion (MA) from ectopic pregnancy (EP). ► Trophoblastic ANG-1 and ANG-2 mRNA expression levels are different in EP compared to failed pregnancies.