Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease - Dermatitis herpetiformis

► First-time evaluation of neo-epitope (Neo) ELISA in dermatitis herpetiformis (DH) ► Higher levels of Neo-IgA/IgG autoantibodies in DH on a normal diet than gluten restricted diet ► Adult controls with cutaneous autoimmunity tested negative in Neo-epitope ELISA ► Superior sensitivities of the neo-epitope ELISA compared with tTg or eTg ELISA ► Neo-epitope autoantibodies represent a novel and sensitive marker of DH.