Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians

► Higher prevalence of TT genotype and T allele of OPN C-443T polymorphism. ► This was associated with nearly threefold increased risk of DN. ► Enhanced proteinuria & lower eGFR among patients carrying TT genotype. ► First study suggesting an association of TT genotype & T allele with D.