Demystifying ethnic/sex differences in kidney function: Is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?

► How well does the CKD-EPI equation for African-American and Asian subjects performs? ► This study presents mathematical analysis of the CKD-EPI equation. ► Literature overview of median/reference serum creatinine values for multiple races. ► Results confirm criticism on the CKD-EPI equation for multiple ethnicities. ► New eGFR model based on population-normalized serum creatinine is proposed.