Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes

► IL-1 family has a central role in regulation of immune and inflammatory responses. ► IL-1 regulates basic metabolic rate, blood glucose levels, blood pressure etc. ► IL-1 family consists of both pro- and anti-inflammatory cytokines. ► IL-1 impairs insulin secretion and induces β-cell apoptosis leading to T2D. ► IL-1 gene polymorphisms are T2D susceptibility indicators in different populations.