Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: Following up on Taiwan's neonatal hepatitis B immunization program

► IL-4 and IL-4R gene SNPs contribute to anti-HBs titers in response to HB vaccine. ► High anti-HBs titers are associated with the IL-4 rs2243250 SNP. ► Individuals carrying the TT genotype have more anti-HBs titer than the CC genotype.