High incidence of severe neutropenia after gemcitabine-based chemotherapy in Chinese cancer patients with CDA 79A>C mutation

► The allele frequencies for CDA A79C and G208A were reported in Chinese population. ► Patients receiving gemcitabine were genotyped for CDA A79C and monitored for toxicity. ► We report the correlation between CDA A79C mutation and gemcitabine-associated toxicity.