Ethylene glycol poisoning: Quintessential clinical toxicology; analytical conundrum

► Ethylene glycol poisoning is a medical emergency. ► Toxicity is caused by the metabolites, glycolic and oxalic acids. ► Effective treatment is available if administered timely. ► Measurement of serum ethylene glycol and glycolic acid establishes the diagnosis and that for glycolic acid is prognostic. ► Methods of measurement for ethylene glycol and glycolic acid, including surrogate measures, are reviewed.