Apelin in acute myocardial infarction and heart failure induced by ischemia

► Only animal studies concern the role of apelin-APJ system in myocardial ischemia. ► Less is known about apelin function in acute phase of myocardial infarction in human. ► Apelin-APJ system could be involved in myocardial protection in acute ischemia. ► Data concerning apelin role in acute myocardial infarction and heart failure have been reviewed.