Cytokeratins in hepatitis

► Cytokeratins are highly expressed in the hepatocyte. ► They can be released after acute or chronic inflammatory liver injury. ► Cytokeratins may serve as biomarkers of hepatocyte necrosis and apoptosis. ► Cytokeratins in serum/plasma are increased in different forms of hepatitis. ► Cytokeratins may be useful for distinguishing fatty liver from steatohepatitis.