Gastric cancer - The role of matrix metalloproteinases in tumor progression

The enhanced levels of various MMPs and TIMPs have been observed in the tissue, plasma and serum of patients with many types of tumor, including gastric cancer. Moreover, levels of MMPs and TIMPs in the tissues as well as in the blood of GC patients correlated with tumor stage, depth of tumor invasion, presence of nodal and distant metastases. Selected MMPs and their tissue inhibitors were proved to be independent prognostic factors for GC patients' survival. However, further studies concerning the role of MMPs and their inhibitors in tumor biology are necessary.