The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1

- Peripheral human lymphocytes are unable to repair oxidized purines such as 8-oxoG.
- The repair of DNA single-strand breaks is slow as well.
- Activation of lymphocytes causes an induction of repair proteins and restores repair.
- The induction of repair precedes the stimulation of cell proliferation.
- Induction of the repair glycosylase OGG1 is mediated by MAP kinases and NF-YA.