کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320741 1539405 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The function of nicotinamide phosphoribosyltransferase in the heart
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The function of nicotinamide phosphoribosyltransferase in the heart
چکیده انگلیسی
In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. Nampt protects the heart from ischemia and reperfusion injury by stimulating Sirt1. In this review, we summarize what is currently known regarding the function of Nampt in the heart.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 23, November 2014, Pages 64-68
نویسندگان
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