Ataxia telangiectasia mutated inhibits oxidative stress-induced apoptosis by regulating heme oxygenase-1 expression

- Transfection with ATM reduces ROS levels by inducing HO-1 in H2O2-exposed AT cells.
- ATM mediates HO-1 expression via activation of PKC-δ and NF-κB.
- HO-1 inhibits oxidative stress-induced apoptosis.