A CHIPotle in physiology and disease

- The review attempts to document an up-to-date understanding on physiological roles of CHIP.
- We summarize new data and discuss how CHIP is involved in various human pathologies ranging from muscular dystrophies through cancer.
- The clinical significance of CHIP and some remaining questions in CHIP biology are discussed.
- Provides arguments for further investigation into CHIP biology with respect to its basic character and clinical potential.