کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8322968 1539889 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miRNA and piRNA mediated Akt pathway in heart: Antisense expands to survive
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
miRNA and piRNA mediated Akt pathway in heart: Antisense expands to survive
چکیده انگلیسی
The Akt signalling pathway is a crucial network of proteins, which plays a role in neonatal cellular proliferation, hypertrophy and cellular survival mechanism in the heart through a multifaceted system including, small non-coding RNAs (sncRNAs). Despite numerous reports on the distorted expression of these proteins in various cardiovascular diseases, this review focuses on the role of miRNA and piRNA in altering Akt signalling. Nevertheless the role of these sncRNAs in the Akt pathway needs to be studied in detail, there are evidence indicating that they can play a vital function in Akt-mediated cardiac survival. Recent reports indicate that, modification of such miRNA/piRNA causes alteration in the Akt pathway during both physiology and pathology. Therefore, understanding the antisense mediated molecular mechanisms of Akt pathway can devise a new vision towards biomarkers and therapeutic approaches to various cardiovascular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 55, October 2014, Pages 153-156
نویسندگان
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