Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth

► Lysophosphatidic acid stimulates expression of ADAM12 in hASCs. ► ADAM12 mediates lysophosphatidic acid-induced differentiation of hASCs to CAFs. ► ADAM12 mediates hASC-stimulated tumor growth. ► ADAM12 stimulates secretion of ECM proteins, periostin and βig-h3, from hASCs.