کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8328276 | 1540205 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dectin-1 mediates the immunoenhancement effect of the polysaccharide from Dictyophora indusiata
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کلمات کلیدی
NF-κBLPS2-aminoacridoneJnkFBSAMACFITCCR3ERKTLR4DIPc-Jun N-terminal kinase - C-Jun N-terminal kinaseMAPK - MAPKinterleukin - اینترلوکینtumor necrosis factor-α - تومور نکروز عامل αDectin-1 - دیکتین-1fetal bovine serum - سرم جنین گاوTNF-α - فاکتور نکروز توموری آلفاImmunostimulatory activity - فعالیت ایمنیfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتlipopolysaccharide - لیپوپلی ساکاریدcomplement receptor type 3 - نوع گیرنده مکمل 3extracellular regulated protein kinases - پروتئین کیناز تنظیم شده خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The polysaccharides (DIP) extracted from Dictyophora indusiate has been found featuring great anti-cancer activity through enhancing organism immunity ability, and the DIP-induced macrophages activation might be mediated via TLR4/NF-κB signaling pathway. In this work, we make further investigation of the effect of DIP on macrophages and whether there was another pathway to regulate the immunoenhancement effect of DIP. The results showed that DIP could activate macrophages, causing the enhancement of its phagocyte activity, and then increase the secretion of IL-1β and TNF-α. It could also activate the MAPK pathway and promoted the phosphorylation and nuclear translocation of NF-κB p65. However, these effects of DIP on macrophage was inhibited by anti-Dectin-1, indicating that besides TLR-4, Dectin-1 act as another receptor on macrophage surface which was responsible for the activation effect of DIP. In conclusion, we further illuminate the molecular mechanism involving in the immune enhancement activities on macrophages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 109, 1 April 2018, Pages 369-374
Journal: International Journal of Biological Macromolecules - Volume 109, 1 April 2018, Pages 369-374
نویسندگان
Chao Deng, Haitian Fu, Jingying Shang, Jinghua Chen, Xin Xu,