کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8333850 | 1540263 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of N-trimethyl chitosan/alginate complexes and curcumin release
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of N-trimethyl chitosan/alginate complexes and curcumin release Characterization of N-trimethyl chitosan/alginate complexes and curcumin release](/preview/png/8333850.png)
چکیده انگلیسی
N-trimethyl chitosan of two quaternization degrees, DQÂ =Â 20 and 80Â mol% and labeled as TMC20 and TMC80, were synthesized and characterized by 1H NMR. Polyelectrolyte complexes (PECs) of TMC/alginate (TMC/ALG) were prepared at pHs 2, 7 and 10 by mixing the aqueous solutions of unlike polymers. The PECs were characterized through infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG) and wide-angle X-ray scattering (WAXS). Using the TMC of DQÂ =Â 20Â mol% and following the same methodology for preparing the PECs, beads of TMC20/ALG were obtained at pH 2 and loaded with curcumin (CUR) at pH 6.0-6.5. The morphology of the beads was evaluated by scanning electron microscopy (SEM). Studies in vitro of the controlled release of CUR from beads were investigated in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) and treated using conventional and partition-diffusion models. Results indicated that the beads based on TMC20 and ALG presented potential as drug-carrier to improve the solubility and biological activity of CUR at pH close to physiological one.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 174-184
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 174-184
نویسندگان
Alessandro F. Martins, Pedro V.A. Bueno, Elizângela A.M.S. Almeida, Francisco H.A. Rodrigues, Adley F. Rubira, Edvani C. Muniz,