کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8334274 | 1540268 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radio-protective effect of polysaccharides isolated from Lactobacillus brevis-fermented Ecklonia cava
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Radio-protective effect of polysaccharides isolated from Lactobacillus brevis-fermented Ecklonia cava Radio-protective effect of polysaccharides isolated from Lactobacillus brevis-fermented Ecklonia cava](/preview/png/8334274.png)
چکیده انگلیسی
We investigated the radioprotective effects of a polysaccharide isolated from enzymatic extracts of Ecklonia cava (E. cava) fermented by fungi and bacteria. We identified that the aqueous extract of the Lactobacillus brevis-fermented E. cava especially showed the highest proliferation effect. In addition, the enzymatic extract prepared by enzyme-assisted extraction using Viscozyme (VLFE) significantly increased cell proliferation. Further study indicated that the polysaccharides isolated from the >30 kDa fraction of VLFE (VLFEP) significantly enhanced survival and proliferation effects in γ-ray-irradiated cells. Also, VLFEP markedly reduced the DNA damage, production of reactive oxygen species, and the percentage of Sub-G1 DNA contents caused by γ-ray-irradiation. Moreover, VLFEP modulated the expression levels of p53, Bax, and Bcl-2 via inhibition of IκBα degradation and phosphorylation and NFκB p65 translocation into nuclei. These results demonstrate that VLFEP has radioprotective properties including the modulation of apoptosis via the inhibition of the NFκB signaling pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 52, January 2013, Pages 260-266
Journal: International Journal of Biological Macromolecules - Volume 52, January 2013, Pages 260-266
نویسندگان
WonWoo Lee, Ginnae Ahn, Bae-Jin Lee, W.A.J.P. Wijesinghe, Daekyung Kim, Hyemi Yang, Young Mog Kim, Sun Joo Park, Youngheun Jee, You-Jin Jeon,