کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336237 | 1540452 | 2015 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The centrally projecting Edinger-Westphal nucleus-I: Efferents in the rat brain
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کلمات کلیدی
LHACRFLSODRDfluoro-goldBDACg1BNSTCARTlateral globus pallidusLHbCSCCRF2CRF1cingulate cortex area 1CLicaudal linear nucleus of the rapheDRVLPBEWcpCorticotropin-releasing factor receptorscuneate fasciculusCECDTGCorpus callosumLGPCGADABCelDRCCPUCEMLSICTBBLAHRP3,3′-diaminobenzidine - 3،3'-diaminobenzidineBSA - BSAcaudate-putamen - Caudate-Putamenbovine serum albumin - آلبومین سرم گاوEfferents - اترنت هاUrocortin 1 - اوروکورتن 1lateral ventricle - بطن جانبیthird ventricle - بطن سومfourth ventricle - بطن چهارمbiotinylated dextran amine - بیوترنیته دیستران آمینcocaine- and amphetamine-regulated transcript - دستورالعمل تنظیم شده کوکائین و آمفتامینBlood vessel - رگ خونیcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینFacial nerve - عصب صورتfornix - فورنیکسinfralimbic cortex - قشر infralimbicprimary motor cortex - قشر حرکتی اولیهCerebellum - مخچهlateral hypothalamic area - منطقه هیپوتالاموس جانبیEdinger–Westphal nucleus - هستن Edinger-Westphaloculomotor nucleus - هسته oculomotorinferior olivary nuclei - هسته ایلومری پایین ترbed nucleus of the stria terminalis - هسته تخت ترمینال های استریLateral habenular nucleus - هسته حنجره جانبیdorsal raphe nucleus - هسته رافهlateral septal nucleus - هسته سپتوم جانبیlateral superior olivary nucleus - هسته فوقانی ایلواری بالاDorsal tegmental nucleus - هسته قشر پشتیfacial nucleus - هسته چهرهStress response - پاسخ به استرسHorseradish peroxidase - پراکسیداز هوررادیشcentral canal - کانال مرکزیcholera toxin subunit B - کلسترول توکسین BCbl - کلمanterior commissure - کمربند قدامیinternal capsule - کپسول داخلیciliary ganglion - گانگلیون تلخی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The oculomotor accessory nucleus, often referred to as the Edinger-Westphal nucleus [EW], was first identified in the 17th century. Although its most well known function is the control of pupil diameter, some controversy has arisen regarding the exact location of these preganglionic neurons. Currently, the EW is thought to consist of two different parts. The first part [termed the preganglionic EW-EWpg], which controls lens accommodation, choroidal blood flow and pupillary constriction, primarily consists of cholinergic cells that project to the ciliary ganglion. The second part [termed the centrally projecting EW-EWcp], which is involved in non-ocular functions such as feeding behavior, stress responses, addiction and pain, consists of peptidergic neurons that project to the brainstem, the spinal cord and prosencephalic regions. However, in the literature, we found few reports related to either ascending or descending projections from the EWcp that are compatible with its currently described functions. Therefore, the objective of the present study was to systematically investigate the ascending and descending projections of the EW in the rat brain. We injected the anterograde tracer biotinylated dextran amine into the EW or the retrograde tracer cholera toxin subunit B into multiple EW targets as controls. Additionally, we investigated the potential EW-mediated innervation of neuronal populations with known neurochemical signatures, such as melanin-concentrating hormone in the lateral hypothalamic area [LHA] and corticotropin-releasing factor in the central nucleus of the amygdala [CeM]. We observed anterogradely labeled fibers in the LHA, the reuniens thalamic nucleus, the oval part of the bed nucleus of the stria terminalis, the medial part of the central nucleus of the amygdala, and the zona incerta. We confirmed our EW-LHA and EW-CeM connections using retrograde tracers. We also observed moderate EW-mediated innervation of the paraventricular nucleus of the hypothalamus and the posterior hypothalamus. Our findings provide anatomical bases for previously unrecognized roles of the EW in the modulation of several physiologic systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 68, October 2015, Pages 22-38
Journal: Journal of Chemical Neuroanatomy - Volume 68, October 2015, Pages 22-38
نویسندگان
Edmilson D. Dos Santos Júnior, André V. Da Silva, Kelly R.T. Da Silva, Carlos A.S. Haemmerle, Daniella S. Batagello, Joelcimar M. Da Silva, Leandro B. Lima, Renata J. Da Silva, Giovanne B. Diniz, Luciane V. Sita, Carol F. Elias, Jackson C. Bittencourt,