کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336348 | 1540612 | 2018 | 66 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The gut microbiota as a novel regulator of cardiovascular function and disease
ترجمه فارسی عنوان
میکروبیوتومی روده به عنوان یک رژیم جدید برای عملکرد و بیماری قلبی عروقی
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کلمات کلیدی
میکروبیوتا، بیماری قلب و عروقی، میکروبیوم، دیس بیوسی، چاقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The gut microbiome has emerged as a critical regulator of human physiology. Deleterious changes to the composition or number of gut bacteria, commonly referred to as gut dysbiosis, has been linked to the development and progression of numerous diet-related diseases, including cardiovascular disease (CVD). Most CVD risk factors, including aging, obesity, certain dietary patterns, and a sedentary lifestyle, have been shown to induce gut dysbiosis. Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier, which in turn increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of CVD. The aim of the current review is to summarize the available data regarding the role of the gut microbiome in regulating CVD function and disease processes. Particular emphasis is placed on nutrition-related alterations in the microbiome, as well as the underlying cellular mechanisms by which the microbiome may alter CVD risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 56, June 2018, Pages 1-15
Journal: The Journal of Nutritional Biochemistry - Volume 56, June 2018, Pages 1-15
نویسندگان
Micah L. Battson, Dustin M. Lee, Tiffany L. Weir, Christopher L. Gentile,