کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336397 | 1540613 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse
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کلمات کلیدی
ketamine (PubChem CID: 3821)Phosphate-Buffered Saline (PubChem CID: 24978514)Xylazine (Pubchem CID: 5707)HNK-1Axonal regrowthSpinal cord injury - آسیب نخاعیUrsolic acid (PubChem CID: 64945) - اسید اور اسولیک (PubChem CID: 64945)Ursolic acid - اسید اورسولیکDimethyl sulfoxide (PubChem CID: 679) - دی متیل سولفوکسید (PubChem CID: 679)Mouse - موش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Human natural killer-1 (HNK-1) cell antigen is a glycan epitope involved in several neural events, such as neuritogenesis, myelination, synaptic plasticity and regeneration of the nervous system after injury. We have recently identified the small organic compound ursolic acid (UA) as a HNK-1 mimetic with the aim to test its therapeutic potential in the central nervous system. UA, a plant-derived pentacyclic triterpenoid, is well known for its multiple biological functions, including neuroprotective, antioxidant and anti-inflammatory activities. In the present study, we evaluated its functions in a mouse model of spinal cord injury (SCI) and explored the molecular mechanisms underlying its positive effects. Oral administration of UA to mice 1 h after SCI and thereafter once daily for 6 weeks enhanced the regaining of motor functions and axonal regrowth, and decreased astrogliosis. UA administration decreased levels of proinflammatory markers, including interleukin-6 and tumor necrosis factor-α, in the injured spinal cord at the acute phase of inflammation and activated the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways in the injured spinal cord. Taken together, these results suggest that UA may be a candidate for treatment of nervous system injuries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 55, May 2018, Pages 219-228
Journal: The Journal of Nutritional Biochemistry - Volume 55, May 2018, Pages 219-228
نویسندگان
Sudhanshu Sahu, Rong Li, Praveen Kumar Kadeyala, Shisong Liu, Melitta Schachner,