کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336419 | 1540615 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer
ترجمه فارسی عنوان
خواص حفاظتی اسید چرب اشباع شده و اثرات آن در سرطان سینه مرتبط با چاقی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Obesity is well documented as a risk factor for developing breast cancer, especially in postmenopausal women. Adipose tissue in the breast under obese conditions induces inflammation by increasing macrophage infiltration and pro-inflammatory cytokines that in turn up-regulates genes and signaling pathways, resulting in increased inflammation, cell proliferation and tumor growth in the breast. Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk. Here, we briefly review current status of breast cancer and its relationship with obesity. We then review in depth, current research and knowledge on the role of n-3 PUFA in reducing/preventing breast cancer cell growth in vitro, in vivo and in human studies, and how n-3 PUFA may modulate signaling pathways mitigating their effects on breast cancer development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 53, March 2018, Pages 1-8
Journal: The Journal of Nutritional Biochemistry - Volume 53, March 2018, Pages 1-8
نویسندگان
Arwa AL-Jawadi, Hanna Moussa, Latha Ramalingam, Suranganie Dharmawardhane, Lauren Gollahon, Preethi Gunaratne, Rakhshanda Layeequr Rahman, Naima Moustaid-Moussa,