کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337075 | 1540655 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome
ترجمه فارسی عنوان
مستعد ابتلا به سرطان، مخاط دهان کولون را حساس می کند تا اثرات رژیم غذایی غربی و تغییرات احتمالی سرطان در پروتئوم موش
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کلمات کلیدی
2D DIGEPPPAINMMRMLH1MutL homolog 1 - MutL همولوگ 1two-dimensional differential gel electrophoresis - الکتروفورز ژل دیفرانسیلی دو بعدیFatty acid oxidation - اکسیداسیون اسید چربmismatch repair - تعمیر ناسازگاریWestern-style diet - رژیم غذایی غربیWestern diet - رژیم غربیColorectal cancer - سرطان روده بزرگLynch syndrome - سندرم لینچFAO - فائوpentose phosphate pathway - مسیر پنتوز فسفاتGene ontology - هستیشناسی ژنیProteomics - پروتئومیکسCRC - کد افزونگی دورهای
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Human epidemiological evidence and previous studies on mice have shown that Western-style diet (WD) may predispose gut mucosa to colorectal cancer (CRC). The mechanisms that mediate the effects of diet on tumorigenesis are largely unknown. To address putative cancer-predisposing events available for early detection, we quantitatively analyzed the proteome of histologically normal colon of a wild-type (Mlh1+/+) and an Mlh1+/â mouse after a long-term feeding experiment with WD and AIN-93G control diet. The Mlh1+/â mouse carries susceptibility to colon cancer analogous to a human CRC syndrome (Lynch syndrome). Remarkably, WD induced expression changes reflecting metabolic disturbances especially in the cancer-predisposed colon, while similar changes were not significant in the wild-type proteome. Overall, the detected changes constitute a complex interaction network of proteins involved in ATP synthesis coupled proton transport, oxidoreduction coenzyme and nicotinamide nucleotide metabolic processes, important in cell protection against reactive oxygen species toxicity. Of these proteins, selenium binding protein 1 and galectin-4, which directly interact with MutL homolog 1, are underlined in neoplastic processes, suggesting that sensitivity to WD is increased by an Mlh1 mutation. The significance of WD on CRC risk is highlighted by the fact that five out of six mice with neoplasias were fed with WD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 25, Issue 11, November 2014, Pages 1196-1206
Journal: The Journal of Nutritional Biochemistry - Volume 25, Issue 11, November 2014, Pages 1196-1206
نویسندگان
Denis Äermadi, Satu Valo, Marjaana Pussila, Nima Reyhani, Laura Sarantaus, Maciej Lalowski, Marc Baumann, Minna Nyström,