Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes

▸ We performed genome-wide ChIP-seq analysis on coactivators and corepressors during 1,25(OH)2D3 treatments. ▸ The coactivator SRC-1 was most highly correlated with VDR/RXR during 1,25(OH)2D3 activation. ▸ Corepressors NCoR and SMRT were also recruited to activation complexes near genes stimulated by 1,25(OH)2D3. ▸ NCoR showed an increased association with VDR only after 1,25(OH)2D3 treatment, as exemplified by the gene c-FOS.