1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

▸ Global VDR null mice are predisposed to chemical- or UVB-induced skin tumor formation. ▸ Wnt/beta-catenin signaling alters in the keratinocytes/epidermis of VDR null mice. ▸ VDR may protect UVB-induced skin cancer via interacting with Wnt/beta-catenin pathway. ▸ There is an increase in skin tumor formation in K14-driven, tamoxifen-induced VDR and beta-catenin conditional knock out mice after long-term exposure to UVB irradiation.