Bimodal binding and free energy of the progesterone receptor in the induction of female sexual receptivity by progesterone and synthetic progestins

► Synthetic progestins potency on female sexual behavior response. ► Physicochemical properties of synthetic progestins. ► Dual mode on progestin binding to the progesterone-receptor. ► Free energy of progestins to progesterone-receptor binding. ► Polar pharmacophores and hydrophobic interactions of synthetic progestins to the PR.