کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8340190 | 1541198 | 2017 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Methods for molecular imaging of brain tumours in a hybrid MR-PET context: Water content, T2â, diffusion indices and FET-PET
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کلمات کلیدی
DTIT2∗MR-PETStandardised uptake valueFETSNRDKIADCQuantitative MRI - MRI کمیMRI - امآرآی یا تصویرسازی تشدید مغناطیسیdiffusion tensor imaging - تصویربرداری تانسور انتشارMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیBrain tumours - تومورهای مغزPositron emission tomography - توموگرافی گسیل پوزیترونlongitudinal relaxation time - زمان آرامش طولیtransverse relaxation time - زمان آرامش عرضیecho time - زمان اکوRepetition time - زمان تکرارapparent diffusion coefficient - ضریب انتشار آشکارMagnetic field strength - قدرت میدان مغناطیسیgrey matter - ماده خاکستریwhite matter - ماده سفیدSUV - ماشین شاسی بلندCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیWater content - محتوای آبfractional anisotropy - ناپیوستگی کسریSignal-to-noise ratio - نسبت سیگنال به نویزGyromagnetic ratio - نسبت گرما مغناطیسیPET - پت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study is to present and evaluate a multiparametric and multi-modality imaging protocol applied to brain tumours and investigate correlations between these different imaging measures. In particular, we describe a method for rapid, non-invasive, quantitative imaging of water content of brain tissue, based on a single multiple-echo gradient-echo (mGRE) acquisition. We include in the processing a method for noise reduction of the multi-contrast data based on Principal Component Analysis (PCA). Noise reduction is a key ingredient to obtaining high-precision water content and transverse relaxation T2â values. The quantitative method is applied to brain tumour patients in a hybrid MR-PET environment. Active tumour tissue is identified by means of FET-PET; oedema, white and grey-matter segmentation is performed based on MRI contrasts. Water content information is not only relevant by itself, but also as a basis for correlations with other quantitative measures of water behaviour in tissue and interpreting the microenvironment of water. Water content in active tumour tissue (84%) and oedema (79%) regions is found to be higher than that of normal WM (69%) and close to that of normal GM (83%). Consistent with literature reports, mean kurtosis is measured to be lower in tumour and oedema regions than in normal WM and GM, whereas mean diffusivity is increased. Voxel-based correlations between water content and diffusion indices obtained with diffusion kurtosis tensor imaging, and between quantitative MRI and FET-PET are reported for 8 brain tumour patients. The effective transverse relaxation time T2â is found to be the MR parameter showing the strongest correlations with other MR indices derived here and with FET-PET.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 130, 1 November 2017, Pages 135-151
Journal: Methods - Volume 130, 1 November 2017, Pages 135-151
نویسندگان
A.M. Oros-Peusquens, R. Loução, M. Zimmermann, K.-J. Langen, N.J. Shah,