کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8341574 | 1541453 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of the nucleotide sugar transporters (SLC35 family) in health and disease
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کلمات کلیدی
UDP-N-acetylgalactosamineUGTUDP-GalNacUDP-GlcAEctonucleoside triphosphate diphosphohydrolaseGFTUDP-GlcNAcUDP-N-acetylglucosamineUDP-galactose transporterGDP-fucose transporterCMP-sialic acid transporterCSt - CSTPAPs - PAP هاUDP-glucuronic acid - اسید UDP-گلوکورونیکGolgi apparatus - دستگاه GolgiEndoplasmic reticulum (ER) - رتیکولوم اندوپلاسمی (ER)nucleotide sugars - قندهای نوکلئوتیدیGlycosylation - گلیکوزیله شدن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nucleotide sugars and adenosine 3â²-phospho 5â²-phosphosulfate (PAPS) are transported from the cytosol to the endoplasmic reticulum (ER) and the Golgi apparatus where they serve as substrates for the glycosylation and sulfation of proteins, lipids and proteoglycans. The translocation is accomplished by the nucleotide sugar transporters (NSTs), a family of highly conserved hydrophobic proteins with multiple transmembrane domains that are part of the solute carrier family 35 (SLC35). NSTs are antiporters responsible not only for transporting nucleotide sugars and PAPS into the Golgi, but also for the transport of the reaction products back to the cytosol. The initial reaction products - the nucleoside diphosphates - must be first converted to nucleoside monophosphates by a group of enzymes called ectonucleoside triphosphate diphosphohydrolases (ENTPDs) before they can exit the Golgi. The transport role of NSTs is essential to glycosylation and development. Mutations in two NST genes, SLC35A1 and SLC35C1, have been related to congenital disorder of glycosylation II (CDG II).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 34, Issues 2â3, AprilâJune 2013, Pages 590-600
Journal: Molecular Aspects of Medicine - Volume 34, Issues 2â3, AprilâJune 2013, Pages 590-600
نویسندگان
Zhiwei Song,