The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis

► Mutant Sialidase enzyme activity can be rescued by chemical chaperones and proteosomal inhibitors. ► Inhibition of proteosome potentiates targeting of misfolded Sialidase to the lysosome. ► This work identifies drugs that can treat Sialidosis, a lysosomal storage disease.