کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8345106 | 1541612 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship between plasma and salivary NOx
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Several studies have shown that fasting plasma nitrite (NO2â) is an indicator of endothelial nitric oxide synthase (NOS) activity while plasma nitrate (NO3â) or the sum of NO2â and NO3â (NOx) does not reflect NOS function. Plasma NO2â can also be elevated through dietary NO3â where the NO3â is partially reduced to NO2â by oral bacteria and enters the plasma through the digestive system. NO3â is taken up from plasma by salivary glands and the cycle repeats itself. Thus, one may propose that salivary NO2â is an indicator of plasma NO2â and consequently of NO production. Many brands of nitric oxide (NO) saliva test strips have been developed that suggest that their product is indicative of circulatory NO availability. However, data supporting a relationship between salivary and plasma NO2â or NO bioavailability are lacking. Here we have measured basal salivary and plasma NO2â and NO3â to determine if any correlation exists between these in 13 adult volunteers. We found no significant correlation between basal salivary and plasma NO2â. Also no correlation exists between salivary NO3â and plasma NO2â. However, we did see a correlation between salivary NO3â and plasma NO3â, and between salivary NO2â and plasma NO3â. In a separate study, we compared the efficiency of salivary NO3â reduction with the efficacy of increasing plasma NO3â and NO2â after drinking beet juice, a high NO3â-containing beverage, in 10 adult volunteers. No significant correlation was observed between the ex vivo salivary reduction of NO3â to NO2â and plasma increases in NO3â or NO2â. These results suggest that measures of salivary NO3â, NO2â or NOx are not good indicators of endothelial function. In addition, the efficiency of saliva to reduce NO3â to NO2âex-vivo does not demonstrate one's ability to increase plasma NO2â following consumption of dietary NO3â.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 47, 1 May 2015, Pages 85-90
Journal: Nitric Oxide - Volume 47, 1 May 2015, Pages 85-90
نویسندگان
William H. Clodfelter, Swati Basu, Crystal Bolden, Patricia C. Dos Santos, S. Bruce King, Daniel B. Kim-Shapiro,