کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8349938 | 1541817 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum
ترجمه فارسی عنوان
متابولیسم دوپامین و سروتونین همراه با پاداش مورفین و مهار آن با بوزیرین: مطالعه در روتاریوم موش صحرایی
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کلمات کلیدی
5-HIAA5-HTDOPACCPPNAC5-hydroxytryptamineVTABuspirone3,4-dihydroxyphenylacetic acid - 3،4-دی هیدروکسی فنیل اسیدهای اسید5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدAddiction - اعتیاد analysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceconditioned place preference - ترجیح محل موظف استsubstantia nigra - توده سیاهDopamine - دوپامینDorsal raphé - رفسنجی پشتیSerotonin - سروتونینmorphine - مورفینNucleus accumbens - هسته accumbenscaudate nucleus - هسته دم دارhomovanillic acid - هومووانیلیک اسیدHVA - چه5-HT1A receptors - گیرنده های 5-HT1A
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Adaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with buspirone. To understand the neurochemical mechanism involved in morphine addiction and its inhibition with buspirone, present study determines the effects of buspirone, morphine and their co-administration on the metabolism of serotonin and dopamine in the NAc and CN. We find that rewarding effects of morphine are associated with an enhancement and attenuation of dopamine metabolism, respectively in the CN and NAc. Serotonin metabolism is enhanced in both regions. Co-administration of buspirone not only prevents rewarding effects of morphine, but its effects on the metabolism of dopamine and serotonin in the NAc and CN are also reversed. Results suggest that 5-HT1A receptor dependent modulation of dopamine neurotransmission in the CN and NAc is involved in the modulation of the rewarding effects of morphine in buspirone co-treated animals. The findings documenting an important role of 5-HT1A receptors in drug addiction suggest that synthetic opioid drugs with agonist activity of 5-HT1A receptors may prove non addictive analgesics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 170, July 2018, Pages 71-78
Journal: Pharmacology Biochemistry and Behavior - Volume 170, July 2018, Pages 71-78
نویسندگان
Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salman,