Antagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats

Although 15 mg/kg norBNI was ineffective in antagonizing the aversive effects of THC, 30 mg/kg norBNI blocked the ability of THC to induce a place aversion. The results of the latter assessment are consistent with prior research with transgenic manipulations of the KOR and provide further evidence for the role of the KOR system in the aversive properties of THC.