کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8350457 1541849 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine
ترجمه فارسی عنوان
درمان ترجیحی محل پیشگیری از هیدرات کلرال، اثر متقابل مورفین را متوقف می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 135, August 2015, Pages 60-63
نویسندگان
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