کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350712 | 1541853 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant
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کلمات کلیدی
5-HTs.c.i.v.FSLi.p.5-HTTDRN5-HT3 receptor - 5-HT3 گیرندهMajor depressive disorder - اختلال افسردگی عمدهondansetron - ایندانسترونanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceIntravenous injection - تزریق داخل وریدیSubcutaneous injection - تزریق زیر جلدی5-HT transporter - حمل کننده 5-HTintraperitoneal - داخل صفاقیAntidepressants - داروهای ضد افسردگیSerotonin - سروتونینFlinders sensitive line - فلیندرز حساس خطSSRI - مهارکنندههای بازجذب سروتونینdorsal raphe nucleus - هسته رافهParoxetine - پاروکستین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
More effective treatments for major depression are needed. We studied if the selective 5-HT3 receptor antagonist ondansetron can potentiate the antidepressant potential of the selective serotonin (5-HT) reuptake inhibitor (SSRI) paroxetine using behavioral, neurochemical and electrophysiological methods. Flinders Sensitive Line (FSL) rats, treated with ondansetron, and/or a sub-effective dose of paroxetine, were assessed in the forced swim test. The effects of an acute intravenous administration of each compound alone and in combination were evaluated with respect to 5-HT neuronal firing rate in the dorsal raphe nucleus (DRN). Effects of s.c. administration of the compounds alone and in combination on extracellular levels of 5-HT were assessed in the ventral hippocampus of freely moving rats by microdialysis. The results showed that ondansetron enhanced the antidepressant activity of paroxetine in the forced swim test. It partially prevented the suppressant effect of paroxetine on DRN 5-HT neuronal firing and enhanced the paroxetine-induced increase of hippocampal extracellular 5-HT release. These findings indicate that 5-HT3 receptor blockade potentiates the antidepressant effects of SSRIs. Since both paroxetine and ondansetron are used clinically, it might be possible to validate this augmentation strategy in depressed patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 131, April 2015, Pages 136-142
Journal: Pharmacology Biochemistry and Behavior - Volume 131, April 2015, Pages 136-142
نویسندگان
C. Bétry, D. Overstreet, N. Haddjeri, A.L. Pehrson, C. Bundgaard, C. Sanchez, A. Mørk,