کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351429 | 1541867 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A possible mechanism for the anxiolytic-like effect of gallic acid in the rat elevated plus maze
ترجمه فارسی عنوان
یک مکانیسم احتمالی برای اثرات آنکسیولیتیک مانند اسید گالیکیک در موش صحرایی به علاوه لانه گزینی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
This work was performed to characterize the possible mechanisms involved in the anxiolytic-like activity of gallic acid (GA) in the rat elevated plus maze (EPM) test. Male Wistar rats were acutely treated with a single dose of GA (10-500Â mg/kg, i.p.) or diazepam and buspirone, 30Â min prior to behavioral assessment in the EPM, open-field and rotarod tests. Treatment with GA markedly produced an increase in the time spent and entries in the open arms of EPM at doses of 30 and 300Â mg/kg, respectively. These effects were comparable to those of the diazepam (1Â mg/kg, i.p.) and buspirone (1Â mg/kg, i.p.). Pretreatment with benzodiazepine antagonist flumazenil (3Â mg/kg, i.p.) partially blocked the anxiolytic-like effect of GA. However, an increase in the time spent and entries in the open arms of EPM observed with GA treatment were significantly inhibited by the 5-HT1A receptor antagonist WAY-100635 (0.5Â mg/kg, i.p.). In the open-field test, only GA at a dose of 500Â mg/kg decreased locomotor activity in rats. Moreover, GA (10-300Â mg/kg, i.p.) or diazepam and buspirone did not alter motor coordination in the rotarod test. These results indicate that GA is an effective anxiolytic agent at low doses, while at the highest dose it has sedative effect. Also this study suggests that the anxiolytic-like activity of GA is primarily mediated by the 5-HT1A but not benzodiazepine receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 117, February 2014, Pages 40-46
Journal: Pharmacology Biochemistry and Behavior - Volume 117, February 2014, Pages 40-46
نویسندگان
Mohammad Taghi Mansouri, Mohammad Soltani, Bahareh Naghizadeh, Yaghoub Farbood, Ahmad Mashak, Alireza Sarkaki,