کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351604 | 1541872 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Related functions of mGlu4 and mGlu8
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Metabotropic glutamate receptors modulate glutamatergic and GABAergic neurotransmission. Our previous pharmacological data indicate that metabotropic receptor 4 (mGlu4) and metabotropic receptor 8 (mGlu8) might have related and overlapping functions. We explored this by analyzing the behavioral phenotypes of mice deficient in either (mGlu4â/â or mGlu8â/â) or both receptors (mGlu4/8â/â). Our analysis focused on measures of anxiety in the open field and elevated zero maze, sensorimotor function on the rotarod and fear conditioning, as mGlu4 and/or mGlu8 were shown to affect performance in these tests. mGlu8â/â mice weighed more than mGlu4/8â/â mice. In the open field, mGlu4â/â mice showed lower levels of anxiety than mGlu8â/â and mGlu4/8â/â mice. In the elevated zero maze, mGlu4â/â mice showed lower levels of anxiety than wild-type, mGlu8â/â and mGlu4/8â/â mice. In the open field, but not elevated zero maze, mGlu4â/â mice showed lower activity levels than wild-type, mGlu8â/â and mGlu4/8â/â mice. mGlu4/8â/â female mice showed less contextual freezing than wild-type and mGlu4â/â female mice and there was a trend toward less freezing in male mGlu4/8â/â than wild-type male mice. There were no genotype differences in cued fear conditioning. There were significant negative correlations between body weight and fall latency on the rotarod in wild-type, mGlu8â/â and mGlu4/8â/â, but not mGlu4â/â, mice. These data suggest related functions of mGlu4 and mGlu8 in behavioral performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 111, October 2013, Pages 11-16
Journal: Pharmacology Biochemistry and Behavior - Volume 111, October 2013, Pages 11-16
نویسندگان
Matthew J. Davis, Robert M. Duvoisin, Jacob Raber,