کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8351604 1541872 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Related functions of mGlu4 and mGlu8
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Related functions of mGlu4 and mGlu8
چکیده انگلیسی
Metabotropic glutamate receptors modulate glutamatergic and GABAergic neurotransmission. Our previous pharmacological data indicate that metabotropic receptor 4 (mGlu4) and metabotropic receptor 8 (mGlu8) might have related and overlapping functions. We explored this by analyzing the behavioral phenotypes of mice deficient in either (mGlu4−/− or mGlu8−/−) or both receptors (mGlu4/8−/−). Our analysis focused on measures of anxiety in the open field and elevated zero maze, sensorimotor function on the rotarod and fear conditioning, as mGlu4 and/or mGlu8 were shown to affect performance in these tests. mGlu8−/− mice weighed more than mGlu4/8−/− mice. In the open field, mGlu4−/− mice showed lower levels of anxiety than mGlu8−/− and mGlu4/8−/− mice. In the elevated zero maze, mGlu4−/− mice showed lower levels of anxiety than wild-type, mGlu8−/− and mGlu4/8−/− mice. In the open field, but not elevated zero maze, mGlu4−/− mice showed lower activity levels than wild-type, mGlu8−/− and mGlu4/8−/− mice. mGlu4/8−/− female mice showed less contextual freezing than wild-type and mGlu4−/− female mice and there was a trend toward less freezing in male mGlu4/8−/− than wild-type male mice. There were no genotype differences in cued fear conditioning. There were significant negative correlations between body weight and fall latency on the rotarod in wild-type, mGlu8−/− and mGlu4/8−/−, but not mGlu4−/−, mice. These data suggest related functions of mGlu4 and mGlu8 in behavioral performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 111, October 2013, Pages 11-16
نویسندگان
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