The effect of acute tyrosine phenylalanine depletion on emotion-based decision-making in healthy adults

► We gave 40 healthy adults a brain dopamine (DA) depleting beverage or a control. ► Pre/post-beverage prolactin levels supported the manipulation's success. ► Iowa Gambling Task (IGT) deck choices did not differ by beverage group. ► However, response time changes for bad decks revealed different IGT response styles. ► DA depletion may have blunted reward salience, making punishments more salient.