Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

► Our Results solidify the suggested link between depression and oxidative stress. ► CoQ10 induces antidepressant-like activity in rats exposed to CRS. ► CoQ10 displays anxiolytic-like effect in rats exposed to CRS. ► CoQ10 prevents hippocampal Oxidative/Nitrosative DNA damage induced by CRS. ► Further research is needed to define the mechanism of CoQ10 behavioral effects.