کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8354292 | 1541923 | 2016 | 69 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recent progress on the characterization of aldonolactone oxidoreductases
ترجمه فارسی عنوان
پیشرفت اخیر در توصیف الدینالاکتون اکسیدوردوکتاز
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کلمات کلیدی
flavin adenine dinucleotideFMNALOGLDHD-arabinono-1,4-lactone oxidasel-Gulono-1,4-lactoneVanillyl alcohol oxidaseVAOl-Galactono-1,4-lactonel-Galactono-1,4-lactone dehydrogenase - l-Galactono-1،4-lactone dehydrogenaseAscorbate - آسکوربات یا ویتامین ثFAD - بدflavin mononucleotide - فلاون مونونوکلئوتیدGuo - گواgulonolactone oxidase - گولونولاکتون اکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
چکیده انگلیسی
l-Ascorbic acid (ascorbate, AsA, vitamin C) is essential for animal and plant health. Despite our dependence on fruits and vegetables to fulfill our requirement for this vitamin, the metabolic network leading to its formation in plants is just being fully elucidated. There is evidence supporting the operation of at least four biosynthetic pathways leading to AsA formation in plants. These routes use d-mannose/l-galactose, l-gulose, d-galacturonate, and myo-inositol as the main precursors. This review focuses on aldonolactone oxidoreductases, a subgroup of the vanillyl alcohol oxidase (VAO; EC 1.1.3.38) superfamily, enzymes that catalyze the terminal step in AsA biosynthesis in bacteria, protozoa, animals, and plants. In this report, we review the properties of well characterized aldonolactone oxidoreductases to date. A shared feature in these proteins is the presence of a flavin cofactor as well as a thiol group. The flavin cofactor in many cases is bound to the N terminus of the enzymes or to a recently discovered HWXK motif in the C terminus. The binding between the flavin moiety and the protein can be either covalent or non-covalent. Substrate specificity and subcellular localization differ among the isozymes of each kingdom. All oxidases among these enzymes possess dehydrogenase activity, however, exclusive dehydrogenases are also found. We also discuss recent evidence indicating that plants have both l-gulono-1,4-lactone oxidases and l-galactono-1,4-lactone dehydrogenases involved in AsA biosynthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Plant Physiology and Biochemistry - Volume 98, January 2016, Pages 171-185
Journal: Plant Physiology and Biochemistry - Volume 98, January 2016, Pages 171-185
نویسندگان
Siddique I. Aboobucker, Argelia Lorence,