Contribution of caveolin-1 to ventricular nitric oxide in age-related adaptation to hypovolemic state

► Ventricular nitric oxide synthases and caveolin-1 during hypovolemic state and aging. ► Aging and acute hemorrhage upregulate nitric oxide synthase activity. ► Caveolin-1/eNOS interaction is involved in aged-related adaptation to hypovolemic state.