Postconditioning with curaglutide, a novel GLP-1 analog, protects against heart ischemia-reperfusion injury in an isolated rat heart

► Curaglutide is a novel, proteolysis resistant GLP-1 analog. ► Curaglutide was cardioprotective in rat hearts ex vivo, when administered after ischemia. ► This cardioprotection consisted of diminished infarct size and decreased hypercontracture. ► Curaglutide cardioprotection was mediated by GLP-1 receptors.