Valsartan, a specific angiotensin II receptor blocker, inhibits pancreatic fluid secretion via vagal afferent pathway in conscious rats

► Valsartan significantly decreased volume of pancreatic juice, but not protein output. ► Valsartan did not affect hormone-stimulated pancreatic secretion. ► Atropine and capsaicin abolished effect of valsartan on pancreatic juice secretion. ► RAS seems to stimulate pancreatic juice secretion via cholinergic afferent pathway.