The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7)

► Our data highlight mechanisms of modulation of insulin signaling by Ang-(1-7). ► Ang-(1-7) reverts acute in vivo Ang II-mediated inhibition of insulin signaling. ► Ang-(1-7) restores insulin signaling in fructose-fed rats. ► These actions of Ang-(1-7) disappear in presence of a Mas receptor antagonist. ► Our data shows that Ang-(1-7) modulates insulin action through the Mas receptor.