Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice

► Pulmonary administered palmitic acid-exendin-4 greatly prolonged hypoglycemia. ► Such prolongation was due to delayed absorption and albumin-binding. ► We consider that this exendin-4 derivative has a potential as a type 2 anti-diabetics.