Identification of a novel Brain Derived Neurotrophic Factor (BDNF)-inhibitory factor: Regulation of BDNF by Teneurin C-terminal Associated Peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells

► Teneurin C-terminal associated peptide (TCAP)-1 inhibits BDNF in vitro. ► The teneurin-TCAP system is a novel system that regulates BDNF. ► The N38 cell line is a model for BDNF regulation. ► This study links the teneurin-TCAP system with BDNF and cocaine seeking.