Neonatal endotoxin exposure changes neuroendocrine, cardiovascular function and mortality during polymicrobial sepsis in adult rats

► We evaluated the effect of neonatal LPS exposure in adult response to CLP. ► LPS exposure increased vasopressin and corticosterone levels. ► Also, reduced hypotension, bacteremia and mortality rate. ► Neonatal LPS exposure improves response to sepsis in adulthood.