Ghrelin- and growth hormone secretagogue receptor-immunoreactive cells in Xenopus pancreas

► We investigated ghrelin- and its receptor-immunoreactive cells in Xenopus pancreas. ► Ghrelin-cells corresponded to insulin-containing cells. ► Receptor-cells corresponded to insulin- and somatostatin-containing cells. ► Metabolic regulation by ghrelin is widely conserved in vertebrate pancreas.